1.
Indian J Biochem Biophys
;
1991 Jun; 28(3): 219-21
Article
in English
| IMSEAR
| ID: sea-27089
ABSTRACT
Application of external electric field to cell suspension maintained at ice temperature induces pores in the cell membrane. At this stage, a drug added to the cell suspension equilibrates across the membrane. On raising the temperature to 37 degrees C, the pores appear to be sealed as the drug is retained in the cells. This method was used for encapsulation of Co-57 labelled cynocobalamin in rabbit erythrocytes. It was seen from the in vivo biokinetic study of the drug-loaded erythrocytes that the rate of elimination of the drug was considerably reduced as compared to that of the free drug, indicating that drug delivery by electroencapsulation can give a sustained release of the drug.
Subject(s)
Animals , Cobalt Radioisotopes , Drug Carriers , Electric Stimulation/instrumentation , Erythrocyte Membrane/physiology , Metabolic Clearance Rate , Rabbits , Vitamin B 12/administration & dosage
2.
Indian J Exp Biol
;
1988 Nov; 26(11): 860-5
Article
in English
| IMSEAR
| ID: sea-55760
3.
Indian J Biochem Biophys
;
1987 Apr; 24(2): 87-91
Article
in English
| IMSEAR
| ID: sea-26555
4.
Indian J Exp Biol
;
1986 Feb; 24(2): 85-7
Article
in English
| IMSEAR
| ID: sea-59178
5.
Indian J Cancer
;
1985 Dec; 22(4): 308-14
Article
in English
| IMSEAR
| ID: sea-51243
6.
Indian J Biochem Biophys
;
1985 Jun; 22(3): 184-7
Article
in English
| IMSEAR
| ID: sea-26679
Subject(s)
Animals , Erythrocyte Membrane/physiology , Haplorhini , Hemolysis , Humans , Mice , Rabbits , Rats , Sheep , Species Specificity
7.
Article
in English
| IMSEAR
| ID: sea-21908
Subject(s)
Humans , Leukemia/blood , Leukocyte Count , Mercury/blood , Rubidium/blood , Trace Elements/blood
8.
Indian J Exp Biol
;
1981 May; 19(5): 441-4
Article
in English
| IMSEAR
| ID: sea-62197
Subject(s)
Animal Feed/analysis , Animals , Kidney/analysis , Liver/analysis , Male , Neutron Activation Analysis/methods , Rats , Testis/analysis , Trace Elements/analysis
9.
Article
in English
| IMSEAR
| ID: sea-23807
Subject(s)
Animals , Female , Mice , Neutron Activation Analysis , Skin/metabolism , Skin Neoplasms/metabolism , Trace Elements/metabolism
10.
Indian J Exp Biol
;
1978 Jun; 16(6): 685-8
Article
in English
| IMSEAR
| ID: sea-60136